Virus infections and the host response. The physiological response to virus infection is generally initiated at the cellular level following replication (tenOever, 2016). After virus entry, the infected cell detects the presence of virus replication through use of any one of a number of pattern recognition receptors (PRRs) (Janeway and Medzhitov, 2002). These receptors serve […]

An important challenge of contemporary biology and medicine is to establish the relationship between disease phenotypes and disruptions in the underlying cellular functions. In the past decades, substantial efforts have been devoted to a gene-based approach, identifying the specific genetic defects that, together with single nucleotide polymorphisms and copy number variations, predispose an individual to […]